NULL pointer dereference in Htslib

CVE-2026-31964

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. While most alignment records store DNA sequence and quality values, the format also allows them to omit this data in certain cases to save space. Due to some quirks of the CRAM format, it is necessary to handle these records carefully as they will actually store data that needs to be consumed and then discarded. Unfortunately the `CONST`, `XPACK` and `XRLE` encodings did not properly implement the interface needed to do this. Trying to decode records with omitted sequence or quality data using these encodings would result in an attempt to write to a NULL pointer. Exploiting this bug causes a NULL pointer dereference. Typically this will cause the program to crash. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Published · last modified .

CVSS v3 metric

CVSS v3 base score 7.5 (High). Vector: CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:N/I:N/A:H.

EPSS exploit prediction

EPSS: 0.005 (39.6th percentile), scored .

Very low probability of exploitation in the next 30 days; routine patching cadence is appropriate. 40th percentile — 39.6% of CVEs in the catalogue have a lower EPSS than this one. How to read EPSS.

EPSS trend (30 days)EPSS over the last 30 days for CVE-2026-31964: held from 0.003 to 0.005.

EPSS over last 30 days · oldest: 0.003 · newest: 0.005 · change: +0.002

Affected products

Weakness classification (CWE)

References

Frequently asked questions

What is CVE-2026-31964?
CVE-2026-31964 is a high-severity vulnerability in Htslib, classified under NULL Pointer Dereference. CVSS score: 7.5/10. Published 2026-03-18.
How severe is CVE-2026-31964?
High severity. CVSS v3 base score is 7.5 out of 10.