Deserialization in Project-Monai Monai

CVE-2026-100845

MONAI before 1.6.0 contains an unsafe deserialization vulnerability in the NumpyReader class that unconditionally uses numpy.load with allow_pickle=True when loading .npy and .npz files. Attackers can craft malicious .npy files with pickle payloads that execute arbitrary code when loaded through MONAI's standard data pipeline.

Vulnerability class: Insecure Deserialization

Published · last modified .

CVSS v3 metric

CVSS v3 base score 7.8 (High). Vector: CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H.

EPSS exploit prediction

EPSS: 0.002 (10.3th percentile), scored .

Very low probability of exploitation in the next 30 days; routine patching cadence is appropriate. 10th percentile — 10.3% of CVEs in the catalogue have a lower EPSS than this one. How to read EPSS.

EPSS trend (30 days)EPSS over the last 30 days for CVE-2026-100845: held from 0.001 to 0.002.

EPSS over last 30 days · oldest: 0.001 · newest: 0.002 · change: +0.001

Affected products

Weakness classification (CWE)

References

Frequently asked questions

What is CVE-2026-100845?
CVE-2026-100845 is a high-severity vulnerability in Project-Monai Monai, classified under Deserialization of Untrusted Data. CVSS score: 7.8/10. Published 2026-09-27.
How severe is CVE-2026-100845?
High severity. CVSS v3 base score is 7.8 out of 10.