What is CVE-2025-68463?

CVE-2025-68463 is a medium-severity vulnerability in Biopython, classified under Improper Restriction of XML External Entity Reference (XXE). CVSS score: 4.9/10. Published 2025-12-18.

How severe is CVE-2025-68463?

Medium severity. CVSS v3 base score is 4.9 out of 10.

XXE in Biopython

CVE-2025-68463

Bio.Entrez in Biopython through 186 allows doctype XXE.

Vulnerability class: XXE (XML External Entity)

Published 2025-12-18 · last modified 2026-06-17.

CVSS v3 metric

CVSS v3 base score 4.9 (Medium). Vector: CVSS:3.1/AV:N/AC:H/PR:L/UI:N/S:C/C:L/I:N/A:L.

EPSS exploit prediction

EPSS: 0.003 (22.2th percentile), scored 2026-10-03.

Very low probability of exploitation in the next 30 days; routine patching cadence is appropriate. 22nd percentile — 22.2% of CVEs in the catalogue have a lower EPSS than this one. How to read EPSS.

EPSS over last 30 days · oldest: 0.003 · newest: 0.003 · change: -0.000

Affected products

Biopython — versions 0

Weakness classification (CWE)

CWE-611 — Improper Restriction of XML External Entity Reference (XXE)

References

Frequently asked questions

What is CVE-2025-68463?: CVE-2025-68463 is a medium-severity vulnerability in Biopython, classified under Improper Restriction of XML External Entity Reference (XXE). CVSS score: 4.9/10. Published 2025-12-18.
How severe is CVE-2025-68463?: Medium severity. CVSS v3 base score is 4.9 out of 10.