Vulnerability in Oxford Nanopore Technologies Minknow

CVE-2025-54808

Oxford Nanopore Technologies' MinKNOW software at or prior to version 24.11 stores authentication tokens in a file located in the system's temporary directory (/tmp) on the host machine. This directory is typically world-readable, allowing any local user or application to access the token. If the token is leaked (e.g., via malware infection or other local exploit), and remote access is enabled, it can be used to establish unauthorized remote connections to the sequencer. Remote access must be enabled for remote exploitation to succeed. This may occur either because the user has enabled remote access for legitimate operational reasons or because malware with elevated privileges (e.g., sudo access) enables it without user consent. This vulnerability can be chained with remote access capabilities to generate a developer token from a remote device. Developer tokens can be created with arbitrary expiration dates, enabling persistent access to the sequencer and bypassing standard authentication mechanisms.

Published · last modified .

CVSS v3 metric

CVSS v3 base score 7.8 (High). Vector: CVSS:3.1/AV:L/AC:L/PR:L/UI:N/S:U/C:H/I:H/A:H.

EPSS exploit prediction

EPSS: 0.002 (4.4th percentile), scored .

Very low probability of exploitation in the next 30 days; routine patching cadence is appropriate. 4th percentile — 4.4% of CVEs in the catalogue have a lower EPSS than this one. How to read EPSS.

EPSS trend (30 days)EPSS over the last 30 days for CVE-2025-54808: held from 0.002 to 0.002.

EPSS over last 30 days · oldest: 0.002 · newest: 0.002 · change: +0.000

Affected products

Weakness classification (CWE)

References

Frequently asked questions

What is CVE-2025-54808?
CVE-2025-54808 is a high-severity vulnerability in Oxford Nanopore Technologies Minknow, classified under Insufficiently Protected Credentials. CVSS score: 7.8/10. Published 2025-10-23.
How severe is CVE-2025-54808?
High severity. CVSS v3 base score is 7.8 out of 10.