What is CVE-2025-12921?

CVE-2025-12921 is a medium-severity vulnerability in Openclinica Community Edition, classified under Improper Neutralization of Special Elements in Output Used by a Downstream Component (Injection). CVSS score: 4.3/10. Published 2025-11-10.

How severe is CVE-2025-12921?

Medium severity. CVSS v3 base score is 4.3 out of 10.

XPath Injection in Openclinica Community Edition

CVE-2025-12921

A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

EPSS: 0.005 (41.0th percentile) — read the EPSS interpretation.

CVSS v3 metric

CVSS v3 base score 4.3 (Medium). Vector: CVSS:3.1/AV:N/AC:L/PR:L/UI:N/S:U/C:L/I:N/A:N.

Affected products

Openclinica Community Edition — versions 3.0, 3.1, 3.2
Openclinica — versions 3.12.2, 3.13

Weakness classification (CWE)

References

cna@vuldb.com (technical-description, VDB Entry, Third Party Advisory, vdb-entry)
cna@vuldb.com (signature, Permissions Required, permissions-required, VDB Entry)
cna@vuldb.com (VDB Entry, Third Party Advisory, third-party-advisory)
cna@vuldb.com (related, Exploit, Third Party Advisory)
cna@vuldb.com (Exploit, Third Party Advisory, exploit)

Frequently asked questions

What is CVE-2025-12921?: CVE-2025-12921 is a medium-severity vulnerability in Openclinica Community Edition, classified under Improper Neutralization of Special Elements in Output Used by a Downstream Component (Injection). CVSS score: 4.3/10. Published 2025-11-10.
How severe is CVE-2025-12921?: Medium severity. CVSS v3 base score is 4.3 out of 10.